research

4-D Heart Imaging (PC VIPR)

Heart disease is the number one killer in the U.S, and congenital heart disease is the most common birth defect around the world. About five million people in the U.S. have heart failure, and it kills 300,000 people a year. Current lengthy MRI heart imaging technology has led to long waiting lists but remarkable newContinue Reading

Organ Donation Policies Vary Amoung Children’s Hospitals

Children’s Hospitals have widely varying policies on organ donation after cardiac death (DCD), according to researchers, who asked 124 hospitals in the United States, Puerto Rico and Canada about their policies in 2007 and 2008. The study authors received responses from 105 hospitals. They found that 72 percent of them had DCD policies, while policiesContinue Reading

Milrinone Tied to Tachyarrhythmia After Congenital Defect Repair

After repair of congenital heart defects, children are at higher risk for significant tachyarrhythmias early after surgery if they’re given milrinone, according to a study from Tennessee. Milrinone is often used to reduce the risk of low cardiac output syndrome, the investigators noted in a report published online September 7 in the American Journal ofContinue Reading

Preclinical Tests Funded for Pumps for Kids, Infants and Neonates (PumpKIN)

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has awarded four contracts totaling $23.6 million to begin preclinical testing of devices to help children born with congenital heart defects or those who develop heart failure. The four-year program is called Pumps for Kids, Infants, and Neonates (PumpKIN). EachContinue Reading

Growth factor enhances heart regeneration without need for cardiac stem cells

Injured heart tissue normally can’t regrow, but researchers at Children’s Hospital Boston have now laid the groundwork for regenerating heart tissue after a heart attack, in patients with heart failure, or in children with congenital heart defects. In the July 24 issue of Cell, they show that a growth factor called neuregulin1 (NRG1), which isContinue Reading

Subglottic Stenosis

My Chloe was recently sedated for an MRI. Before any images were taken, the anesthesiologist tried to stabilize Chloe’s breathing for 45 minutes and was unsuccessful. She decided to intubate Chloe. She discovered that Chloe has Subglottic Stenosis (SGS). It can be congenital or acquired. With Chloe, it was probably acquired from her previous intubations.Continue Reading

Mixed Results in Comparing Surgeries for CHD

Infants born with a severely underdeveloped heart are more likely to survive to their first birthday when treated with a new shunt procedure — yet it may not be the safest surgery long term, according to research by the University of Michigan Congenital Heart Center.The study results were presented Sunday at the American Heart Association’sContinue Reading

One mystery behind CHD

Until now, the reasons why some children are born with holes in their hearts, or faulty heart valves, have eluded doctors and scientists. Findings published online in the prestigious PNAS journal may hold at least some of the answers. “It’s a great tragedy when children need open heart surgery almost as soon as they areContinue Reading

Plastic Bronchitis (specifically post-Fontan)

Plastic bronchitis is characterized by marked obstruction of the large airways by bronchial casts. Bronchial casts take the shape of the bronchi of a lobe or a lung. These casts may result in mild symptoms or life-threatening disease, and diagnosis is usually made when casts are expectorated or removed by bronchoscopy. Casts are often aContinue Reading

Infants Needing Heart Transplant May Be Able to Accept Heart from Different Blood Type

New findings give infants a greater window of opportunity, better survival odds. A study showing that infants under one year of age can accept heart transplants from donors of different blood groups without the risk of organ rejection means a better chance of survival for infant patients and more efficient use of donor organs overall.Continue Reading