research

Sudden Arrhythmias – What Causes SADS?

The conditions responsible for SADS cause a cardiac arrest by bringing on a ‘ventricular arrhythmia’ (a disturbance in the heart’s rhythm), even though the person has no structural heart disease. There is a group of relatively rare diseases called ion channelopathies that affect the electrical functioning of the heart without affecting the heart’s structure. ThisContinue Reading

Risk of Seizures (ANEs) with Prolonged Deep Hypothermic Circulatory Arrest (DHCA) during Open Heart Surgery

Objective. To identify pre- and intraoperative variables associated with postoperative acute neurologic events (ANEs), including seizures and coma, in newborn survivors of congenital heart surgery undergoing deep hypothermic circulatory arrest (DHCA), and to risk-stratify this population on the basis of preoperative risk variables for the purpose of designing future neuroprotection trials. Methods. Survivors of newbornContinue Reading

Special Bypass Procedure Used During Infant Heart Surgery Does Not Impair Later Neurological Outcomes in Children

Congenital heart defects (CHD) are the most common birth defects in humans, affecting 8 per 1000 live births with one third of affected children requiring intervention in early infancy. Increasing numbers of survivors combined with developmental expectations for independence, behavioral self-regulation and academic achievement have led to a growing identification of neurobehavioral symptoms in someContinue Reading

Children with CHD are at Higher Risk for Sepsis

What is sepsis? Sepsis (SEP-sis) is a serious condition that occurs when your child’s body overreacts to an infection. It is also called systemic inflammatory response syndrome (SIRS) with infection. Infection in sepsis is usually caused by bacteria (germs) that attack the body. Normally, the body’s immune system fights off an infection within the affectedContinue Reading

Vocal Cord Paresis Can Occur After Open Heart Surgery

One of the complications Chloe endured after the Arterial Switch Operation was Left Vocal Cord Paresis (weakness in the left vocal fold). Cardiac surgery represents a risk to normal voice function as the nerves serving the larynx (voice box) are routed near the heart. Damage to this nerve during open heart surgery is not uncommon.Continue Reading

Milrinone Tied to Tachyarrhythmia After Congenital Defect Repair

After repair of congenital heart defects, children are at higher risk for significant tachyarrhythmias early after surgery if they’re given milrinone, according to a study from Tennessee. Milrinone is often used to reduce the risk of low cardiac output syndrome, the investigators noted in a report published online September 7 in the American Journal ofContinue Reading

Sudden Cardiac Death in Children & Adolescents

Sudden cardiac death in children and adolescents is rare but seems to be more frequent than previously reported. The occurrence of such an event is very devastating. Primary caretakers should be aware of the etiologies and the importance of screening. This article will discuss etiologies of sudden cardiac death in children and adolescents and willContinue Reading

Preclinical Tests Funded for Pumps for Kids, Infants and Neonates (PumpKIN)

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has awarded four contracts totaling $23.6 million to begin preclinical testing of devices to help children born with congenital heart defects or those who develop heart failure. The four-year program is called Pumps for Kids, Infants, and Neonates (PumpKIN). EachContinue Reading

Cardiac Ablation

Normally, electricity flows throughout the heart in a regular, measured pattern. This normally operating electrical system is the basis for heart muscle contractions. Sometimes, the electrical flow gets blocked or travels the same pathways repeatedly creating something of a “short circuit” that disturbs normal heart rhythms. Medicine often helps. In some cases, however, the mostContinue Reading

Growth factor enhances heart regeneration without need for cardiac stem cells

Injured heart tissue normally can’t regrow, but researchers at Children’s Hospital Boston have now laid the groundwork for regenerating heart tissue after a heart attack, in patients with heart failure, or in children with congenital heart defects. In the July 24 issue of Cell, they show that a growth factor called neuregulin1 (NRG1), which isContinue Reading